منابع مشابه
Chemoselective nitration of aromatic sulfonamides with tert-butyl nitrite.
A methodology for the efficient conversion of aromatic sulfonamides into their mono-nitro derivatives using tert-butyl nitrite is reported. The reaction exhibits a high degree of chemoselectivity for sulfonamide functionalized aryl systems, even in the presence of other sensitive or potentially reactive functionalities.
متن کاملRegioselective synthesis of nitrosoimidazoheterocycles using tert-butyl nitrite.
A simple and practical method has been developed for the regioselective nitrosylation of imidazopyridines via C(sp(2))-H bond functionalization using tert-butyl nitrite under mild reaction conditions in a short time. A library of 3-nitrosoimidazopyridines with broad functionalities was synthesized in near quantitative yields. The present protocol is also applicable to imidazo[2,1-b]thiazole and...
متن کاملDopaminergic Effects of Isobutyl Nitrite, Isoamyl Nitrite and Butyl Nitrite
Alkyl nitrites have been problematic worldwide due to their recreational use. Although there is a lack of scientific information on their action on the central nervous system (CNS), many anecdotal reports and case studies have inferred the CNS actions of alkyl nitrites. The objective of this study was to investigate the effects of alkyl nitrites on the CNS, especially focusing on the dopaminerg...
متن کاملAerobic radical multifunctionalization of alkenes using tert-butyl nitrite and water
Water induces a change in the product of radical multifunctionalization reactions of aliphatic alkenes involving an sp(3) C-H functionalization by an 1,5-hydrogen shift using tert-butyl nitrite and molecular oxygen. The reaction without water, reported previously, gives nitrated γ-lactols, whereas the reaction in the presence of water produces 4-hydroxy-5-nitropentyl nitrate or 4-hydroxy-3-nitr...
متن کاملSynthesis of Hindered Anilines: Three-Component Coupling of Arylboronic Acids, tert-Butyl Nitrite, and Alkyl Bromides.
The synthesis of sterically hindered amines has been a significant challenge in organic chemistry. Herein, we report a modular, three-component coupling that constructs two carbon-nitrogen bonds including a sterically hindered Csp3-N bond using commercially available materials. This process uses an earth-abundant copper catalyst and mild reaction conditions, allowing access to a variety of comp...
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ژورنال
عنوان ژورنال: Synlett
سال: 2011
ISSN: 0936-5214,1437-2096
DOI: 10.1055/s-0030-1259948